Composite Polyvinylpyrrolidone–Sodium Alginate—Hydroxyapatite Hydrogel Films for Bone Repair and Wound Dressings Applications

Fadeeva, I.V.; Trofimchuk, E.S.; Forysenkova, A.A.; Ahmed, A.I.; Gnezdilov, O.I.; Davydova, G.A.; Kozlova, S.G.; Antoniac, A.; Rau, J.V.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 12 января 2022 г.

Авторы: Fadeeva Inna V., Trofimchuk Elena S., Forysenkova Anna A., Ahmed Abdulrahman I., Gnezdilov Oleg I., Davydova Galina A., Kozlova Svetlana G., Antoniac Aurora, Rau Julietta V.
Журнал: Polymers
Том: 13
Номер: 22
Год издания: 2021
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Номер статьи: 3989
DOI: 10.3390/polym13223989
Аннотация: Today, the synthesis of biocompatible and bioresorbable composite materials such as “polymer matrix-mineral constituent,” which stimulate the natural growth of living tissues and the restoration of damaged parts of the body, is one of the challenging problems in regenerative medicine. In this study, composite films of bioresorbable polymers of polyvinylpyrrolidone (PVP) and sodium alginate (SA) with hydroxyapatite (HA) were obtained. HA was introduced by two different methods. In one of them, it was synthesized in situ in a solution of polymer mixture, and in another one, it was added ex situ. Phase composition, microstructure, swelling properties and biocompatibility of films were investigated. The crosslinked composite PVP-SA-HA films exhibit hydrogel swelling characteristics, increasing three times in mass after immersion in a saline solution. It was found that composite PVP-SA-HA hydrogel films containing HA synthesized in situ exhibited acute cytotoxicity, associated with the presence of HA synthesis reaction byproducts—ammonia and ammonium nitrate. On the other hand, the films with HA added ex situ promoted the viability of dental pulp stem cells compared to the films containing only a polymerPVP-SA blend. The developed composite hydrogel films are recommended for such applications,such as membranes in osteoplastic surgery and wound dressing.
Добавил в систему: Трофимчук Елена Сергеевна

	ИСТИНА	Войти в систему Регистрация
	ИПМех РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

ИПМех РАН

Composite Polyvinylpyrrolidone–Sodium Alginate—Hydroxyapatite Hydrogel Films for Bone Repair and Wound Dressings Applicationsстатья

Прикрепленные файлы