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Role of IL-6 in experimental arthritis caused by transfer of arthritogenic antibodiesстатья
Информация о цитировании статьи получена из
Scopus
Дата последнего поиска статьи во внешних источниках: 11 мая 2017 г.
- Авторы: Drutskaya M.S., Gorshkova E.A., Zhdanova A.S., Atretkhany K.S., Gogoleva V.S., Zvartsev R.V., Kruglov A.A., Nedospasov S.A.
- Журнал: Medical Immunology (Russia)/Meditsinskaya Immunologiya
- Том: 18
- Номер: 6
- Год издания: 2016
- Первая страница: 569
- Последняя страница: 574
- DOI: 10.15789/1563-0625-2016-6-569-574
- Аннотация: Interleukin-6 (IL-6) exerts important functions on immune regulation. In case of high expression, IL-6 may promote autoimmune disorders, e.g., arthritis. Systemic IL-6 blockers based on monoclonal antibodies against IL-6, or its specific receptor subunit, are already used in clinical settings, adding to a range of known biological drugs, such as, TNF blockers. Rheumatic disorders and their experimental therapy are reproducible in mice. This study revealed systemically increased levels of IL-6 in developing arthritis caused by transfer of pathogenic antibodies, as well as the effects of IL-6 neutralization by monoclonal antibodies against murine IL-6. Our results suggest a pathogenic role of the two cytokines, TNF and IL-6, in experimental arthritis induced by passive transfer of anti-collagen antibodies
- Добавил в систему: Атретханы Камар-Сулу Нияз кызы