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Hsp150, Pir1 and Cis3 were identified as lipid-associated proteins of Saccharomyces cerevisiae cell wall indepently of Bgl2 presenceстатья Тезисы
- Авторы: Arzhanik Vladimir K., Bykova Anastasia A., Ziganshin Rustam H., Kudryashova Irina B.
- Сборник: Mycology 2020, Cutting edge research, optimal patient care
- Год издания: 2020
- Место издания: The QE2 Conference Centre, London
- Первая страница: 155
- Последняя страница: 156
- Аннотация: Hsp150 and to a lesser extent Pir1 and Cis3 of Saccharomyces cerevisiae clinical isolates are important virulence proteins (IVP) (Hsu et al., 2015). A major conservative glucanosyltransglycosylase Bgl2 is present in Candida albicans and Saccharomyces cerevisiae cell walls (CW) and characterized by adhesive and amyloid-like properties (Jeng et al.,2005;Kalebina et al.,2008). It was shown that C.albicans with BGL2 deletion is less virulent than wild-type strain (Sarthy et al.,1997). It was recently demonstrated that lipid-associated microcompartments is the important part of CW for the localization of different proteins with functional activity (Vargas et al.,2015;Rekstina et al.,2019). Objectives of this investigation: to find out whether the difference in virulence of wt and bgl2Δ strains could be explained by the presence or absence of Bgl2 in the lipid-associated fraction of CW.
- Добавил в систему: Калебина Татьяна Сергеевна