Аннотация:Saccadic eye-movements are informative model for research of adaptive behavior cognitive control. Cognitive functions of attention, decision-making and inhibition as various stages of saccade programming are reflected in parameters and topography of ERP components (Slavutskaya et al., 2008). Saccadic eye-movement dysfunctions are observed in a lot of mental illnesses, however the neuronal mechanisms of its violation are poorly understood in the initial stages of shizophrenia.The aim of the study is to identify EEG markers of attention, decision making and inhibition processes as a components of cognitive control and their impairments in patients at ultra-high risk (UHR) of schizophrenia, which can be predictive for early diagnosis of schizophrenia. In 20 healthy subjects and 20 UHR of schizophrenia patients (right - handed men of 18-20 years old) the parameters and topography of P1, N1, P2, N2 and P3 ERP components associated with the signal stimuli have been studied in the "Go / No go" saccadic paradigm. The “Go” or “No go” visual stimuli were in the form of white circles or crosses on the dark display. They were presented at the 7 degrees distance from the central fixation point on the left or right. Eye movements were recorded using EOG. EEG was recorded from 25 head leads. The method of selective EEG averaging before saccades with the mean latentcy (LP) ± 20-30 ms of the average value) were use.There were found the differences in peak topography and the spatiotemporal dynamics of the ERP components in two groups, which may indicate diversity in the spatial organization of cognitive control neural networks in normal and UHR of schizophrenia. In the patients group, the peaks of the ERP components were mainly localized in the cortex fronto-central areas, which may reflect the processes of neurocompensation in the conditions of “frontal deficiency” and decrease of prefrontal top-down effects at the pre-manifest stage of schizophrenia.Thus, the analysis of the Go” and “No go” stimuli ERP parameters and topography indicate a violation of the sensory perception, spatial attention, and result monitoring in UHR patients. The obtained data suggest a complicated trajectory of the cognitive disturbance development at the pre-manifest stage of schizophrenia, which is accompanied by a partial preservation of the right hemisphere neuronal mechanisms at the stage of sensory processing and by partial left hemisphere mechanisms preservation at the stage of result monitoring and memory updating.