Аннотация:The study of structure – anti-tubulin activity relationship for 5-hydroxymethyl-2-methoxyphenyl adamantane-1-acetate led to the discovery of 1-[2-(5-(hydroxymethyl)-2-methoxyphenyl)ethyl]adamantane, which exhibits a dual-target profile and retains in vitro activity observed for the lead-compound, but is more stable metabolically.
