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Red and blue light in antitumor photodynamic therapy with chlorin-based photosensitizers: a comparative animal study assisted by optical imaging modalitiesстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или ScopusДата последнего поиска статьи во внешних источниках: 15 декабря 2021 г.
- Авторы: Kirillin Mikhail, Kurakina Daria, Khilov Aleksandr, Orlova Anna, Shakhova Maria, Orlinskaya Natalia, Sergeeva Ekaterina
- Журнал: Biomedical optics express
- Том: 12
- Номер: 2
- Год издания: 2021
- Издательство: Optical Society of America
- Местоположение издательства: United States
- Первая страница: 872
- Последняя страница: 892
- DOI: 10.3390/cancers13225807
- Аннотация: Fluorescence imaging is an efficient tool in monitoring photodynamic therapy procedures allowing us to track accumulation and photobleaching of a photosensitizer (PS). Chlorin-based PSs feature high absorption in the red and blue bands of visible spectrum. Due to spectral dispersion of light penetration depth in biotissues, fluorescence signals registered upon excitation by red or blue light are formed in different measurement volumes. We present analytical and numerical models of dual-wavelength fluorescence imaging for evaluation of PS localization depth in the cases of topical administration and intravenous injection. The results of analytical and numerical simulations are in good agreement with the phantom experiments, and are translated to the in vivo imaging, which allows to interpret experimental observations in animal trials, human volunteers, and clinical studies. The proposed approach allows us to noninvasively estimate typical accumulation depths of PS localization which are consistent with the morphologically expected values.
- Добавил в систему: Сергеева Екатерина Александровна