You shall not pass: Ti nanospike-based sterilizer in fluid flow reactorстатья
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Дата последнего поиска статьи во внешних источниках: 22 декабря 2021 г.
Аннотация:Abstract:We report the laser-ablative fabrication of antibacterial nanostructures, combining mechanical and chemotoxic effects, by femto- and nanosecond laser ablation and their testing on Staphylococcus aureus and Pseudomonas aeruginosa strains. A Ti surface, covered with nanospikes and periodical surface ripples, provides a strong anti-biofilm effect, and the addition of cytotoxic nanoparticles (NPs) (Ag, Se) enhances the overall bactericidal activities. A flow reactor, including Ti nanospike-covered wafers as a through-flow sterilizer, allowed reduction of the bacterial population by two orders. Several types of nanostructures with/without biofilms were characterized by scanning electron microscopy and energy-dispersive x-ray spectroscopy. Their antibacterial properties were demonstrated by standard live/dead tests and were suggested to originate from the combined chemical toxicity of NPs and mechanical damage caused by sharp nanoscale relief on Ti.