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Combination of magnetic resonance relaxometry and ASL perfusion in assessment of high-grade glioma subregions and surrounding brain tissueтезисы доклада
- Авторы: Chekhonin I., Batalov A., Tyurina A., Pogosbekian E., Nikitin P., Bykanov A., Zakharova N., Pitskhelauri D., Pronin I.N.
- Сборник: The ECR 2021 Book of Abstracts - Insights into Imaging
- Серия: Volume 12 Supplement 2
- Тезисы
- Год издания: 2021
- Первая страница: 270
- Последняя страница: 270
- Номер статьи: RPS 311-5
- DOI: 10.1186/s13244-021-01014-5
- Аннотация: Purpose: To assess the capability of MR relaxomery and ASL perfusion to differentiate between regions of malignant gliomas and areas of surroundingbrain tissue.Methods or Background: 27 patients older than 18 years with newly diagnosed contrast-enhancing supratentorial glial tumors were enrolled. The MRI protocol (1.5 T) contained conventional stuctural MRI (including contrastenhanced images), pseudocontinuous ASL perfusion and magnetic resonance image compilation (MAGiC). Before tumor resection, the following ROIs on relaxometric and ASL maps were chosen: - area of maximal perfusion within contrast-enhancing tumor part (1); - perifocal infiltrative edema (non-enhancing T2 FLAIR hyperintensive) zone (2) - normal-appearing tumor-adjacent white (3) and gray (6) matter along the operative approach - normal-appearing white (4) and gray (5) matter remote from the tumor zone. Statistics included Kruskal-Wallis and Bonferroni-corrected Mann-Whitney tests, ROC analysis and Spearman correlation.Results or Findings: There were 18 patients with glioblastoma, 5 patients with anaplastic oligodendroglioma, 4 patients with anaplastic astrocytoma. Cerebral blood flow (CBF) allowed to differentiate between zones 1 and 2 with higher values in zone 1. T1, T2 and proton density values could differentiate between zones 2 and 3 with higher values in zone 2. T2 values could also afford to discriminate between zones 3 and 4 with lower values in zone 3. No difference was shown between relaxomertic or perfusion properties of zones 5 and 6. Significant inverse correlation was found between T2 and CBF in zone 1. Conclusion: ASL perfusion and MR relaxometry possess complementary power for differentiation of glioma subregions and adjacent brain matter and thus represent a rationale for combined application.Limitations: Sample size. Possible anatomical differences in relaxometric values between brain regions independent of tumor presence.
- Добавил в систему: Чехонин Иван Владимирович