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Non-invasive prostate cancer screening using chemometric processing of macro and trace element concentration profiles in urineстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 26 января 2022 г.
- Авторы: Martynko Ekaterina, Oleneva Ekaterina, Andreev Evgeny, Savinov Sergey, Solovieva Svetlana, Protoshchak Vladimir, Karpushchenko Evgenii, Sleptsov Aleksandr, Panchuk Vitaly, Legin Andrey, Kirsanov Dmitry
- Журнал: Microchemical Journal
- Том: 159
- Год издания: 2020
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 105464
- DOI: 10.1016/j.microc.2020.105464
- Аннотация: We report on the attempt to develop a simple non-invasive screening protocol for prostate cancer (PCa). Absolute concentrations of 19 macro and trace elements (Ag, Al, B, Ba, Ca, Cd, Cu, Fe, K, Mg, Mn, Na, P, Pb, S, Si, Sr, Tl, Zn) were determined using inductively coupled plasma optical emission spectroscopy (ICP-OES) and atomic absorption spectroscopy (AAS) techniques in 34 urine samples from patients with biopsy-confirmed PCa and 32 urine samples from controls. All the possible concentration ratios were calculated as well. Various data processing methods, including Principal Component Analysis, Logistic Regression, and Decision Trees, were applied for data modeling to study if the elemental concentration profile may contribute to the development of new screening tools for prostate cancer. Several statistically significant differences between the two groups were observed both in the individual element concentrations and in their ratios. The mathematical classification models built for the prediction of the patient's status with respect to PCa based on elemental profile have shown the accuracy of up to 89%, thus exceeding the accuracy of the standard prostate-specific antigen testing.
- Добавил в систему: Плющенко Иван Викторович