Аннотация:Event-based sampling of isotopes in precipitation (δ18O and δ2H) was done in a large European Moscow city (Russian Federation) to understand modern climate variability and isotopic sensitivity to air temperature and precipitation amount.A strong seasonality of δ18O and δ2H values, with a maximum in summer and a minimum in winter, was a consequence of the temperature effect as expressed by significant correlation (r = 0.76). Compared with historical monthly values (Global Network of Isotopes in Precipitation in 1970–1979), event-based stable isotope values in monthly means were lower in March and October and slightly higher in summer due to larger variability in precipitation amount of some events and, particularly, by an increase of the precipitation amount amplitude in last years, relative to the long-term. The isotopic signature of somemonthly precipitation values was determined by the predominant role of one or two events, which provide up to 50% of the monthly value. A wide range of d-excess values from − 8.7 to + 27.9‰ for individual events was associated with a frequent change in air masses trajectories moving through Moscow, high mobility of atmospheric transport and cyclonic activity.The low correlation of δ18O values with the North Atlantic Oscillation (NAO) index, absence of the significant relationship between NAO, air temperature and precipitation amount were indicative for a partial effect of the NAO on the precipitationpatterns and isotopic composition of precipitation in Moscow. The study provides a first background for understanding of hydrometeorological processes using event based isotopic signature in East European precipitation.