Effect of Methyl-β-Cyclodextrin on the Interaction of Fluoroquinolones with Human Serum Albumin

Yakupova, L.R.; Kopnova, T.Y.; Skuredina, A.A.; Kudryashova, E.V.

Авторы: Yakupova L.R., Kopnova T.Yu, Skuredina A.A., Kudryashova E.V.
Журнал: Russian Journal of Bioorganic Chemistry
Том: 48
Номер: 1
Год издания: 2022
Издательство: Maik Nauka/Interperiodica Publishing
Местоположение издательства: Russian Federation
Первая страница: 125
Последняя страница: 134
DOI: 10.1134/S1068162022010149
Аннотация: The influence of the structure of fluoroquinolones (on the example of ciprofloxacin and levofloxacin) and their complexation with methyl-β-cyclodextrin on the interaction of the drug with human serumalbumin was studied. It was found that the binding of the drug molecule with albumin is significantly affectedby the structure of fluoroquinolone, as well as the presence of methyl-β-cyclodextrin. It was discovered thatof the two fluoroquinolones, the more hydrophobic ciprofloxacin molecule interacts more strongly with theprotein, using circular dichroism and fluorescence spectroscopy methods. It has also been shown that binding of albumin to the drug causes quenching of protein fluorescence, and this effect is more pronounced forciprofloxacin. The complexation of fluoroquinolones with methyl-β-cyclodextrin leads to a change in theinteraction of fluoroquinolones with the protein: in the case of complexes, more pronounced interactions areobserved for levofloxacin. The results obtained will help to bring the use of fluoroquinolones to a new levelin clinical practice, by creating new highly effective drugs with improved properties.
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