Genetic Engineering Systems to Study Human Viral Pathogens from the Coronaviridae Familyстатья
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Дата последнего поиска статьи во внешних источниках: 4 марта 2022 г.
Аннотация:The COVID-19 pandemic caused by the previously unknown SARS-CoV-2 Betacoronavirus made it extremely important to develop simple and safe cellular systems which allow manipulation of the viral genome and high-throughput screening of its potential inhibitors. In this review, we made an attempt at summarizing the currently existing data on genetic engineering systems used to study not only SARS-CoV-2, but also other viruses from the Coronaviridae family. In addition, the review covers the basic knowledge about the structure and the life cycle of coronaviruses.