Аннотация:Alzheimer's disease(AD) is an irreversible neurodegenerative disease caused by many reasons. It is the
most common type of dementia. It is mainly characterized by progressive memory loss, cognitive
impairment, inattention, affective disorder and personality change. Its incidence is closely related to age,
genetic factors and environmental factors[1,2]. With the vigorous economic development, accelerated
aging process and serious environmental pollution, the prevalence of AD has increased sharply. Drug
treatment for AD has always been a research hotspot. Preclinical screening of relevant new drugs is being
carried out on a large scale all over the world, but most of them end in failure. At present, only five kinds
are approved for treatment, all of which are acetylcholinesterase inhibitors and glutamate receptor
antagonists, but it can only slow down the symptoms and cannot change the disease process[3].
Lonicerae Japonicae Flos, a dried flower bud or newly opened flower of Lonicera japonica Thunb, a
plant of the genus Lonicera in the Lonicerae Japonicae Flos family, is a common traditional Chinese
medicine with a long history, which is mainly distributed in Henan, Shandong, Guangdong and other
places[4]. Lonicerae Japonicae Flos is sweet in taste and cold in nature. It enters the heart, lung and
stomach meridian. Its effect is mainly to clear away heat and detoxify. It is mainly used to treat febrile
diseases, fever, carbuncle and gangrene toxin, heat toxin and blood dysentery. It has a variety of
pharmacological effects and is widely used in clinical practice[5].The results showed that the aqueous
extract of Lonicerae Japonicae Flos could prevent hippocampal amyloid β The accumulation of protein and
the enhancement of insulin signal transduction in hippocampus decreased TNF-αand iNOS in hippocampal
mice, prevent cognitive impairment and reverse fat oxidation[6]. Each dose group of Lonicerae Japonicae
Flos leaf flavone can promote the increase of body mass, liver index, spleen index, heart index and brain
index of mice to varying degrees, effectively enhance the physique of aging mice, and slow down the brain
atrophy and the decline of organ function of mice[7].
Due to the complex and diverse components of Lonicerae Japonicae Flos, this study takes the
pharmacodynamic components of Lonicerae Japonicae Flos with anti-ad effect as the research object, and
analyzes the functional components, targets and mechanism of honeysuckle in the remedy of AD through
network pharmacological methods, so as to provide more scientific evidence for the use of honeysuckle in
the treatment of AD.