Synthesis and molecular structure of 4-{[6-((2SR,4SR)-4-acetyl- 4-methylpyrrolidin-2-yl)-2-(4-cyanophenoxy)pyrimidin- 4-yl]oxy}-3,5-dimethylbenzonitrile and 4-[(6-{(2SR,4SR)-4-acetyl- 1-[(4-bromophenyl)sulfonyl]-4-methylpyrrolidin-2-yl}- 2-(4-cyanophenoxy

Авторы: Sokolov Nikita А., Ivanov Vladimir N., Iusupov Ildar R., Iasevich Anton V., Trubnikov Artem V., Ulianova Yuliya V., Lyssenko Konstantin А., Kurkin Alexander V.
Журнал: Chemistry of Heterocyclic Compounds
Том: 58
Номер: 1
Год издания: 2022
Издательство: Kluwer Academic/Plenum Publishers
Местоположение издательства: United States
Первая страница: 64
Последняя страница: 67
DOI: 10.1007/s10593-022-03057-y
Аннотация: A novel diarylpyrimidine derivative, 4-{[6-((2SR,4SR)-4-acetyl-4-methylpyrrolidin-2-yl)-2-(4-cyanophenoxy)pyrimidin-4-yl]oxy}-3,5-dimethylbenzonitrile containing a pyrrolidine moiety at position 6 of the pyrimidine ring was obtained as a result of the tandem aza-Cope/Mannich reaction between 4-{[2-(4-cyanophenoxy)-6-formylpyrimidin-4-yl]oxy}-3,5-dimethylbenzonitrile and 1-amino-2,3-dimethylbut-3-en-2-ol in methylene chloride in the presence of 10-camphorsulfonic acid. The structure of the product of its reactionwith 4-bromobenzenesulfonyl chloride, 4-[(6-{(2SR,4SR)-4-acetyl-1-[(4-bromophenyl)sulfonyl]-4-methylpyrrolidin-2-yl}-2-(4-cyanophenoxy)pyrimidin-4-yl)oxy]-3,5-dimethylbenzonitrile, was investigated by X-ray structural analysis.
Добавил в систему: Куркин Александр Витальевич

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