Lymphocyte subpopulations in melanoma patients treated with dendritic cell vaccines  2007 , Advances in Experimental Medicine and Biology

Авторы: Kadagidze Z.G., Borunova A.A., Zabotina T.N.
Журнал: Advances in experimental medicine and biology
Том: 601
Год издания: 2007
Издательство: Kluwer Academic/Plenum Publishers
Местоположение издательства: United States
Первая страница: 381
Последняя страница: 386
DOI: 10.1007/978-0-387-72005-0_41
Аннотация: The main goal of cancer immunotherapy is to induce or boost tumor-specific effector cells able to eliminate or reduce tumor progression. In this study, we characterized lymphocyte phenotypes in melanoma patients receiving dendritic cell (DC)-based vaccinotherapy. We found that several biological markers served as unfavorable prognostic factors for patients' response to therapy. This included decrease of CD4+ and CD8+ lymphocyte levels, 10% and higher increase of CD16+CD3+CD8+ lymphocyte population, and increase of CD16+CD8+perforin+ T lymphocytes, especially in combination with decreased levels of CDI6+CD8(-)perforin+ and CD8+CD16(-)perforin+ cells. Increase in CD8+CD16(-)perforin+ T lymphocytes with normal levels of CD16+CD8(-)perforin+ cells and the absence of CD16+CD8+perforin+ and regulatory lymphocytes were shown to be the positive prognostic markers for patients' response to DC vaccines.
Добавил в систему: Заботина Татьяна Николаевна

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