Аннотация:The ability of cisplatin, cycloplatam, doxorubicin and etoposide to induce apoptosis was investigated in Jurkat cells using propidium iodide staining, TUNEL method and Annexin V-FITC binding. In spite of the different primary intracellular targets of drugs under study in all the cases drug-induced cytotoxicity ultimately converges on the common pathway causing apoptosis. All the drugs under study induced apoptosis in a time- and dose-dependent manner. Percentage of apoptotic cells determined by TUNEL technique and Annexin V binding in all the cases studied exceeded the apoptosis percentage determined by PI binding assay.