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Is there an advantageous arrangement of aromatic residues in proteins?: Statistical analysis of aromatic interactions in globular proteinsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 марта 2022 г.
- Авторы: Lobanov Mikhail Yu, Pereyaslavets Leonid B., Likhachev Ilya V., Matkarimov Bakhyt T., Galzitskaya Oxana V.
- Журнал: Computational and Structural Biotechnology Journal
- Том: 19
- Год издания: 2021
- Первая страница: 5960
- Последняя страница: 5968
- DOI: 10.1016/j.csbj.2021.10.036
- Аннотация: The aim of this study was to evaluate the favorability of different conformations of aromatic residues in proteins by analysing the occurrence of particular conformations. The clustering of protein structures from the Protein Data Bank (PDB) was performed. Conformations of interacting aromatic residues were analyzed for 511 282 pairs in 35 493 protein structures sharing less than 50% identity. Pairs with a parallel arrangement of aromatic residues made up 6.2% of all possible ones, which was twice as much as expected. Pairs with a perpendicular arrangement of aromatic residues made up 25%. We demonstrate that the most favorable arrangement was at an angle of 60 degrees between the interacting aromatic residues. Among all possible aromatic pairs, the His-His pair was twice as frequent as expected, and the His-Phe pair was less frequent than expected. A server (CARP - Contacts of Aromatic Residues in Proteins) has been created for calculating essential structural features of interacting aromatic residues in proteins: http://bioproteom.protres.ru/arom_q_prog/.
- Добавил в систему: Галзитская Оксана Валериановна