Characteristics of Mel Ibr Melanoma Line Subclone after Treatment with Chicken Embryo Extractстатья
Информация о цитировании статьи получена из
Web of Science ,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 марта 2022 г.
Авторы:
Suraeva N.M. ,
Morozova L.F. ,
Ryabaya O.O. ,
Khochenkova Y.A. ,
Samoilov A.V. ,
Burova O.S. ,
Golubtsova N.V. ,
Barmashov A.E. ,
Baryshnikova M.A.
Журнал:
Bulletin of Experimental Biology and Medicine
Том:
163
Номер:
2
Год издания:
2017
Издательство:
Springer Nature
Местоположение издательства:
Switzerland
Первая страница:
255
Последняя страница:
259
DOI:
10.1007/s10517-017-3778-y
Аннотация:
We continue analysis of the phenotype of human melanoma cell Mel Ibr subclone obtained previously by treatment of the parental cell line by chicken embryo extract. The present study is focused on detection of markers of epithelial-mesenchymal transition that determine enhanced metastatic and invasive potential of malignant tumors of various locations. Analysis of the expression of E-cadherin and vimentin genes in the subclone and parental cells detected activation of epithelial-mesenchymal transition in the subclone. Immunological markers CD90, CD271, and CD95 were present in the parental population, but were not detected on the subclone cells. In contrast to the parental line, cells of the analyzed subclone retain viability in serum-free medium and formed vessel-like structures characteristic of vasculogenic mimicry. © 2017, Springer Science+Business Media, LLC.
Добавил в систему:
Барышникова Мария Анатольевна