Novel prognostic determinants of COVID-19-related mortality: A pilot study on severely-ill patients in Russia

Rubina, K.; Shmakova, A.; Shabanov, A.; Andreev, Y.; Borovkova, N.; Kulabukhov, V.; Evseev, A.; Popugaev, K.; Petrikov, S.; Semina, E.

Информация о цитировании статьи получена из Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 11 апреля 2022 г.

Авторы: Rubina Kseniya, Shmakova Anna, Shabanov Aslan, Andreev Yulii, Borovkova Natalia, Kulabukhov Vladimir, Evseev Anatoliy, Popugaev Konstantin, Petrikov Sergey, Semina Ekaterina
Журнал: PLoS ONE
Том: 17
Номер: 2
Год издания: 2022
Издательство: Public Library of Science
Местоположение издательства: United States
Номер статьи: e0264072
DOI: 10.1371/journal.pone.0264072
Аннотация: COVID-19 pandemic has posed a severe healthcare challenge calling for an integrated approach in determining the clues for early non-invasive diagnostics of the potentially severe cases and efficient patient stratification. Here we analyze the clinical, laboratory and CT scan characteristics associated with high risk of COVID-19-related death outcome in the cohort of severely-ill patients in Russia. The data obtained reveal that elevated dead lymphocyte counts, decreased early apoptotic lymphocytes, decreased CD14+/HLA-Dr+ monocytes, increased expression of JNK in PBMCs, elevated IL-17 and decreased PAI-1 serum levels are associated with a high risk of COVID-19-related mortality thus suggesting them to be new prognostic factors. This set of determinants could be used as early predictors of potentially severe course of COVID-19 for trials of prevention or timely treatment.
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Novel prognostic determinants of COVID-19-related mortality: A pilot study on severely-ill patients in Russiaстатья

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