Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infection

Neves, P.; Lampropoulou, V.; Calderon-Gomez, E.; Roch, T.; Stervbo, U.; Shen, P.; Kühl, A.; Loddenkemper, C.; Haury, M.; Nedospasov, S.; Kaufmann, S.; Steinhoff, U.; Calado, D.; Fillatreau, S.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 14 сентября 2013 г.

Авторы: Neves P., Lampropoulou V., Calderon-Gomez E., Roch T., Stervbo U., Shen P., Kühl AA, Loddenkemper C., Haury M., Nedospasov SA, Kaufmann SH, Steinhoff U., Calado DP, Fillatreau S.
Журнал: Immunity
Том: 33
Номер: 5
Год издания: 2010
Издательство: Cell Press
Местоположение издательства: United States
Первая страница: 777
Последняя страница: 790
DOI: 10.1016/j.immuni.2010.10.016
Аннотация: The myeloid differentiation primary response gene 88 (Myd88) is critical for protection against pathogens. However, we demonstrate here that MyD88 expression in B cells inhibits resistance of mice to Salmonella typhimurium infection. Selective deficiency of Myd88 in B cells improved control of bacterial replication and prolonged survival of the infected mice. The B cell-mediated suppressive pathway was even more striking after secondary challenge. Upon vaccination, mice lacking Myd88 in B cells became completely resistant against this otherwise lethal infection, whereas control mice were only partially protected. Analysis of immune defenses revealed that MyD88 signaling in B cells suppressed three crucial arms of protective immunity: neutrophils, natural killer cells, and inflammatory T cells. We further show that interleukin-10 is an essential mediator of these inhibitory functions of B cells. Collectively, our data identify a role for MyD88 and B cells in regulation of cellular mechanisms of protective immunity during infection.
Добавил в систему: Недоспасов Сергей Артурович

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Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infectionстатья

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