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Lymphotoxin-beta regulates periderm differentiation during embryonic skin developmentстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 14 сентября 2013 г.
- Авторы: Cui CY, Kunisada M., Esibizione D., Grivennikov SI, Piao Y., Nedospasov SA, Schlessinger D.
- Журнал: Human Molecular Genetics
- Том: 16
- Номер: 21
- Год издания: 2007
- Издательство: Oxford University Press
- Местоположение издательства: United Kingdom
- Первая страница: 2583
- Последняя страница: 2590
- DOI: 10.1093/hmg/ddm210
- Аннотация: Lymphotoxin-b (LTb) is a key regulator of immune system development, but also affects late stages in hair development. In addition, high expression of LTb at an early stage in epidermis hinted at a further function in hair follicle induction or epithelial development. We report that hair follicles were normally induced in LTb2/2 skin, but the periderm detached from the epidermis earlier, accompanied by premature appearance of kera- tohyalin granules. Expression profiling revealed dramatic down-regulation of a gene cluster encoding periderm-specific keratin-associated protein 13 and four novel paralogs in LTb2/2 skin prior to periderm detachment. Epidermal differentiation markers, including small proline-rich proteins, filaggrins and several keratins, were also affected, but transiently in LTb2/2 skin at the time of abnormal periderm detachment. As expected, Tabby mice, which lack the EDA gene, the putative upstream regulator of LTb in skin, showed similar though milder periderm histopathology and alterations in gene expression. Overall, LTb shows a primary early function in periderm differentiation, with later transient effects on epidermal and hair follicle differentiation.
- Добавил в систему: Недоспасов Сергей Артурович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | hmg2583.pdf | hmg2583.pdf | 721,2 КБ | 2 августа 2013 [snedos] |