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DNA Methylation Markers For Diagnosis Of Serous Ovarian Cancerстатья
- Авторы: Abramov Pavel M., Vinokurova Svetlana V., Elkin Danila S.
- Журнал: Онкогинекология
- Номер: 4
- Год издания: 2019
- Издательство: Межрегиональная общественная организация "Общество специалистов онкологов по опухолям репродуктивной системы"
- Местоположение издательства: Москва
- Первая страница: 4
- Последняя страница: 16
- DOI: 10.52313/22278710_2019_4_4
- Аннотация: Objective of the study is to conduct systematic analysis of the literature on DNA methylation in ovarian cancer (OC), special emphasis should be placed on DNA methylation as a diagnostic marker of ovarian cancer. Materials and Methods. The review comprises English language publications available in PubMed database in the previous 14 years. Results. Analysis of literature data showed that differential DNA methylation is observed in clinical samples of patients with ovarian cancer. To date, the study of DNA methylation is one the most promising focus area for the development of early diagnosis of ovarian cancer. Differential DNA methylation may be detected not only in tumor tissue but it can be revealed using non-invasive techniques. While considerable progress has been made in this field, literature data are sporadic. Majority of gene methylation sites are described in single publications. But there are well researched, common genes that are reported in many works: RASSF1, BRCA1, MGMT, OPCML, as well as HOXA gene family. Conclusion. The study of aberrant DNA methylation in tumor tissue and biological fluids will allow to develop an approach for early diagnosis of ovarian cancer. Furthermore, aberrant DNA methylation has the potential to be used as a prognostic marker of disease progression and also as treatment selection marker.
- Добавил в систему: Елкин Данила Сергеевич