Determination of the Enantiomeric Purity of Albuterol on Sorbents Modified by Macrocyclic Antibioticsстатья
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Дата последнего поиска статьи во внешних источниках: 13 июня 2017 г.
Аннотация:The separation of albuterol enantiomers on sorbents with macrocyclic glycopeptide antibiotics
immobilized on the silica surface was investigated. Commercial columns—Nautilus-E (BioKhimMak, Russia)
with eremomycin as a chiral selector and ChirobioticTAG (Astec, United States) with teicoplanin aglycone as a chiral selector—were used for enantioseparation. Levalbuterol is the (R)-enantiomer of albuterol.
We managed to separate albuterol enantiomers on both columns in a polar organic mode, but selectivity was higher on the ChirobioticTAG column (Rs = 1.7). The maximum resolution of enantiomer peaks (1.7) was observed in methanol–acetonitrile–triethylamine–acetic acid (90 : 10 : 0.05 : 0.05) as the mobile phase. The detection limit of the compound calculated by a signal–background ratio of 3 : 1 was 0.00002 mg/mL, which corresponds to 0.1% of (S)-enantiomer with respect to the total amount. The results made it possible to determine the enantiomeric purity of the active pharmaceutical substances of levalbuterol.