Phenotypic Plasticity of Cancer Cells Based on Remodeling of the Actin Cytoskeleton and Adhesive Structuresстатья
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 1 апреля 2022 г.
Аннотация:There is ample evidence that, instead of a binary switch, epithelial-mesenchymal transition(EMT) in cancer results in a flexible array of phenotypes, each one uniquely suited to a stage inthe invasion-metastasis cascade. The phenotypic plasticity of epithelium-derived cancer cells givesthem an edge in surviving and thriving in alien environments. This review describes in detail theactin cytoskeleton and E-cadherin-based adherens junction rearrangements that cancer cells need toimplement in order to achieve the advantageous epithelial/mesenchymal phenotype and plasticityof migratory phenotypes that can arise from partial EMT.