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Hydrophilic sulfur-containing antioxidant sodium 3-(3-tert-butyl-4-hydroxyphenyl)propylthiosulfate as a modulator of the activity of antitumor cytostatics and their combinations with a NO donorстатья
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 мая 2022 г.
- Авторы: Bogatyrenko T.N., Kandalintseva N.V., Sashenkova T.E., Allayarova U.Yu, Mishchenko D.V.
- Журнал: Russian Chemical Bulletin
- Том: 71
- Номер: 3
- Год издания: 2022
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- Первая страница: 517
- Последняя страница: 523
- DOI: 10.1007/s11172-022-3442-1
- Аннотация: The interaction of a combination of a sulfur-containing phenolic antioxidant sodium 3-(3-tert-butyl-4-hydroxyphenyl)propylthiosulfate (TS-13) with a nitric oxide donor (NaNO2) and two antitumor cytostatics, cisplatin and doxorubicin, was studied in vivo using a model of P-388 murine leukemia of BDF1 mice. It has been shown that the type of cytostatics used determines the efficiency of chemotherapy. Depending on this, the antioxidant TS-13 can both enhance and reduce the antitumor effect. The use of TS-13 and a nitric oxide donor with different cytostatics and different modes of drug administration modulates their activity in different ways, namely, from increasing survival to inhibition of survival.
- Добавил в систему: Алдошин Сергей Михайлович