Expression Analysis of Genes Involved in Transport Processes in Mice with MPTP-Induced Model of Parkinson’s Disease

Rudenok, M.M.; Shadrina, M.I.; Filatova, E.V.; Rybolovlev, I.N.; Nesterov, M.S.; Abaimov, D.A.; Ageldinov, R.A.; Kolacheva, A.A.; Ugrumov, M.V.; Slominsky, P.A.; Alieva, A.K.

Авторы: Rudenok Margarita M., Shadrina Maria I., Filatova Elena V., Rybolovlev Ivan N., Nesterov Maxim S., Abaimov Denis A., Ageldinov Ruslan A., Kolacheva Anna A., Ugrumov Michael V., Slominsky Petr A., Alieva Anelya Kh
Журнал: Life
Том: 12
Номер: 5
Год издания: 2022
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 751
DOI: 10.3390/life12050751
Аннотация: Processes of intracellular and extracellular transport play one of the most important roles in the functioning of cells. Changes to transport mechanisms in a neuron can lead to the disruption of many cellular processes and even to cell death. It was shown that disruption of the processes of vesicular, axonal, and synaptic transport can lead to a number of diseases of the central nervous system, including Parkinson’s disease (PD). Here, we studied changes in the expression of genes whose protein products are involved in the transport processes (Snca, Drd2, Rab5a, Anxa2, and Nsf) in the brain tissues and peripheral blood of mice with MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced models of PD. We detected changes in the expressions of Drd2, Anxa2, and Nsf at the earliest modeling stages. Additionally, we have identified conspicuous changes in the expression level of Anxa2 in the striatum and substantia nigra of mice with MPTP-induced models of PD in its early stages. These data clearly suggest the involvement of protein products in these genes in the earliest stages of the pathogenesis of PD
Добавил в систему: Абаимов Денис Александрович

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Expression Analysis of Genes Involved in Transport Processes in Mice with MPTP-Induced Model of Parkinson’s Diseaseстатья Исследовательская статья

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