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Structure, nitric oxide (NO) generation and antitumor activity of binuclear tetranitrosyl iron complex with 4-aminothiophenolyl as nitrosyl ferredoxins mimicстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 25 мая 2022 г.
- Авторы: Sanina N.A., Kozub G.I., Kondrat’eva T.A., Stupina T.S., Balakina A.A., Terent’ev A.A., Sulimenkov I.V., Ovanesyan N.S., Dorovatovskii P.V., Khrustalev V.N., Aldoshin S.M.
- Журнал: Journal of Coordination Chemistry
- Том: 74
- Номер: 4-6
- Год издания: 2021
- Издательство: Gordon and Breach Science Publishers
- Местоположение издательства: Switzerland
- Первая страница: 743
- Последняя страница: 761
- DOI: 10.1080/00958972.2020.1869222
- Аннотация: Single-crystal XRD structure of binuclear tetranitrosyliron complex [Fe2(SR)2(NO)4] (1), R = 4-aminothiophenyl, has been described. The properties of 1 were studied by IR, Mössbauer, mass spectroscopy, and amperometry. Complex 1 was shown to form long-living nitrosyl intermediates in solution, which underlies its prolonged NO donor activity. In HeLa cells, 1 caused accumulation of NF-κB p50 but decreased the levels of NF-κB p65 in the nucleus, which led to inhibition of NF-κB dependent genes. The complex also induced increase of p53 protein levels and p21 gene activity, which led to the apoptotic cell death after G2/M cell cycle phase.
- Добавил в систему: Алдошин Сергей Михайлович