Models of Head and Neck Squamous Cell Carcinoma Using Bioengineering Approaches

Bonartsev, A.P.; Lei, B.; Kholina, M.S.; Menshikh, K.A.; Svyatoslavov, D.S.; Samoylova, S.I.; Sinelnikov, M.Y.; Voinova, V.V.; Shaitan, K.V.; Kirpichnikov, M.P.; Reshetov, I.V.

Авторы: Bonartsev Anton P., Lei Bo, Kholina Margarita S., Menshikh Ksenia A., Svyatoslavov Dmitriy S., Samoylova Svetlana I., Sinelnikov Mikhail Y., Voinova Vera V., Shaitan Konstantin V., Kirpichnikov Mikhail P., Reshetov Igor V.
Журнал: Critical Reviews in Oncology/Hematology
Том: 180
Год издания: 2022
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Первая страница: 103724
Номер статьи: 103724
DOI: 10.1016/j.critrevonc.2022.103724
Аннотация: The use of bioengineering methods and approaches is extremely promising for the development of experimentalmodels of cancer, especially head and neck squamous cell carcinomas (HNSCC) that are characterized by earlymetastasis and rapid progression., for testing novel anticancer drugs and diagnostics. This review summarizes themost relevant HNSCC tumor models used to this day as well as future directions for improved modeling of themalignant disease. Apart from conventional 2D-cell cultivation methods and in vivo animal cancer models anumber of bioengineering techniques of modeling HNSCC tumors were reported: genetic-engineering, ethanol/tobacco exposure experiment, spheroids, hydrogel-based cell culture, scaffold-based cell culture, microfluidics,bone-tumor niche cell culture, cancer and normal cells co-culture, cancer cells, and bacteria co-culture. Anorganized set of these models can constitute a system of HNSCC experimental modeling, which gives potentialtowards developing the newest approaches in the diagnosis, prevention, and treatment of HNSCC.
Добавил в систему: Шайтан Константин Вольдемарович

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Models of Head and Neck Squamous Cell Carcinoma Using Bioengineering Approachesстатья

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