Analysis of tumor antigen-specific T cells and antibodies in cancer patients treated with radiofrequency ablation

Widenmeyer, M.; Shebzukhov, Y.; Haen, S.P.; Schmidt, D.; Clasen, S.; Boss, A.; Kuprash, D.V.; Nedospasov, S.A.; Stenzl, A.; Aebert, H.; Wernet, D.; Stevanovic, S.; Pereira, P.L.; Rammensee, H.; Gouttefangeas, C.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.

Авторы: Widenmeyer Melanie, Shebzukhov Yuriy, Haen Sebastian P., Schmidt Diethard, Clasen Stephan, Boss Andreas, Kuprash Dmitri V., Nedospasov Sergei A., Stenzl Arnulf, Aebert Hermann, Wernet Dorothee, Stevanovic Stefan, Pereira Philippe L., Rammensee Hans-Georg, Gouttefangeas Cecile
Журнал: International Journal of Cancer
Том: 128
Номер: 11
Год издания: 2011
Издательство: John Wiley & Sons Inc.
Местоположение издательства: United States
Первая страница: 2653
Последняя страница: 2662
DOI: 10.1002/ijc.25601
Аннотация: Radiofrequency (RF) ablation is a minimally invasive technique routinely applied for the treatment of primary and secondary liver tumors. It induces cell death by thermal coagulative necrosis of tumor tissues, whereas cellular metabolism can still take place in a transition zone surrounding the necrotic area. An increase in heat shock protein expression occurs shortly after treatment, suggesting that the induction of activating signals may stimulate the host immune system. In addition, various effects on immune effectors have also been observed, including stimulation of tumor-directed T lymphocytes. Here, we prospectively assessed the activation of tumor antigen-specific antibodies, as well as antigen-specific CD4(+) and CD8(+) T cells in patients suffering from primary or secondary malignancies and treated by RF ablation with or without concomitant chemotherapy. An increase of antibodies (in 4 patients of 49), CD4(+) T cells or CD8(+) T cells (in 2 patients of 49) could be detected several weeks to months following intervention. These findings suggest that in addition to the local control of tumor growth, RF ablation can provide the appropriate conditions for activating tumor-antigen specific immune responses.
Добавил в систему: Недоспасов Сергей Артурович

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Analysis of tumor antigen-specific T cells and antibodies in cancer patients treated with radiofrequency ablationстатья

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