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Urokinase-Type Plasminogen Activator Enhances the Neuroprotective Activity of Brain-Derived Neurotrophic Factor in a Model of Intracerebral Hemorrhageстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 13 июля 2022 г.
- Авторы: Dzhauari Stalik, Litvinova Svetlana, Efimenko Anastasia, Aleksandrushkina Natalia, Basalova Nataliya, Abakumov Maxim, Danilova Natalia, Malkov Pavel, Balabanyan Vadim, Bezuglova Tatiana, Balayants Viktor, Mnikhovich Maxim, Gulyaev Mikhail, Skryabina Mariya, Popov Vladimir, Stambolsky Dmitry, Voronina Tatiana, Tkachuk Vsevolod, Karagyaur Maxim
- Журнал: BIOMEDICINES
- Том: 10
- Номер: 6
- Год издания: 2022
- Номер статьи: 1346
- DOI: 10.3390/biomedicines10061346
- Аннотация: Brain-derived neurotrophic factor (BDNF) is a classic neuroprotective and pro-regenerative factor in peripheral and central nervous tissue. Its ability to stimulate the restoration of damaged nerve and brain tissue after ischemic stroke and intraventricular hemorrhage has been demonstrated. However, the current concept of regeneration allows us to assert that one factor, even if essential, cannot be the sole contributor to this complex biological process. We have previously shown that urokinase-type plasminogen activator (uPA) complements BDNF activity and stimulates restoration of nervous tissue. Using a model of intracerebral hemorrhage in rats, we investigated the neurotrophic and neuroprotective effect of BDNF combined with uPA. The local simultaneous administration of BDNF and uPA provided effective neuroprotection of brain tissue after intracerebral hemorrhage, promoted survival of experimental animals and their neurological recovery, and decreased lesion volume. The study of cellular mechanisms of the observed neurotrophic effect of BDNF and uPA combination revealed both known mechanisms (neuronal survival and neurite growth) and new ones (microglial activation) that had not been shown for BDNF and uPA. Our findings support the concept of using combinations of biological factors with diverse but complementary mechanisms of action as a promising regenerative approach.
- Добавил в систему: Карагяур Максим Николаевич
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