|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
Evidence that conserved essential genes are enriched for pro-longevity factorsстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Oz Naci, Vayndorf Elena M., Tsuchiya Mitsuhiro, McLean Samantha, Turcios-Hernandez Lesly, Pitt Jason N., Blue Benjamin W., Muir Michael, Kiflezghi Michael G., Tyshkovskiy Alexander, Mendenhall Alexander, Kaeberlein Matt, Kaya Alaattin
- Журнал: GEROSCIENCE
- Том: 44
- Год издания: 2022
- Первая страница: 1995
- Последняя страница: 2006
- DOI: 10.1007/s11357-022-00604-5
- Аннотация: At the cellular level, many aspects of aging are conserved across species. This has been demonstrated by numerous studies in simple model organisms like Saccharomyces cerevisiae, Caenorhabdits elegans, and Drosophila melanogaster. Because most genetic screens examine loss of function mutations or decreased expression of genes through reverse genetics, essential genes have often been overlooked as potential modulators of the aging process. By taking the approach of increasing the expression level of a subset of conserved essential genes, we found that 21% of these genes resulted in increased replicative lifespan in S. cerevisiae. This is greater than the ~ 3.5% of genes found to affect lifespan upon deletion, suggesting that activation of essential genes may have a relatively disproportionate effect on increasing lifespan. The results of our experiments demonstrate that essential gene overexpression is a rich, relatively unexplored means of increasing eukaryotic lifespan.
- Добавил в систему: Тышковский Александр Эдуардович