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Preparation and Characterization of Poly(2-oxazoline) Micelles for the Solubilization and Delivery of Water Insoluble Drugsстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 22 июня 2022 г.
- Авторы: Vinod Natasha, Hwang Duhyeong, Azam Salma, Swearingen Amanda Van, Wayne Elizabeth, Fussell Sloane, Sokolsky Marina, Pecot Chad, Kabanov Alexander
- Журнал: Bio-protocol
- Том: 11
- Номер: 6
- Год издания: 2021
- Первая страница: 1
- Последняя страница: 8
- DOI: 10.21769/bioprotoc.3959
- Аннотация: Many new drug development candidates are highly lipophilic compounds with low water solubility. This constitutes a formidable challenge for the use of such compounds for cancer therapy, where high doses and intravenous injections are needed ( Di et al., 2012 ). Here, we present a poly(2-oxazoline) polymer (POx)-based nanoformulation strategy to solubilize and deliver hydrophobic drugs. POx micelles are prepared by a simple thin-film hydration method. In this method, the drug and polymer are dissolved in a common solvent and allowed to mix, following which the solvent is evaporated using mild heating conditions to form a thin film. The micelles form spontaneously upon hydration with saline. POx nanoformulation of hydrophobic drugs is unique in that it has a high drug loading capacity, which is superior to micelles of conventional surfactants. Moreover, multiple active pharmaceutical ingredients (APIs) can be included within the same POx micelle, thereby enabling the codelivery of binary as well as ternary drug combinations.
- Добавил в систему: Лопухов Антон Владимирович