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Antitumor pharmacological activity of hybrid organotin compounds on the Lewis epidermoid carcinoma modelстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Dodokhova M.A., Kotieva I.M., Safronenko A.V., Alkhuseyn-Kulyaginova M.S., Kotieva E.М., Kotieva V.М., Starostin S.I., Nikitin E.A., Shpakovsky D.B., Milaeva E.R.
- Журнал: Journal of Clinical Oncology
- Том: 40
- Номер: 16 suppl.
- Год издания: 2022
- Издательство: American Society of Clinical Oncology
- Местоположение издательства: United States
- Первая страница: e15004
- Последняя страница: e15004
- DOI: 10.1200/JCO.2022.40.16_suppl.e15004
- Аннотация: Bis-(3,5-di-tert-butyl-4-hydroxyphenyl)dimethyltin(Me-3) and (3,5–di–tert–butyl–4–hydroxyphenylthiolate) triphenyl tin (Me-5) were used as chemotherapeutic agents. Groups of animals were formed as follows: I (experimental) - Me-3 at a dose of 75mg / kg; II (experimental) - Me-5 at a dose of 50 mg / kg; III (control group) - without pharmacological substances. The compounds were injected intraperitoneally daily for 5 days. All animals were euthanized since 21 days after the tumor cells transplantation. The antitumor effect was estimated by the percentage of tumor growth inhibition by weight (%). After the intraperitoneal injection of Me-3 and Me-5 there was revealed an inhibition of growth by weight of Lewis epidermoid carcinoma’s primary node for all experimental groups, 23.7% and 28%respectively. Conclusions: The injection of organotin compounds with different ligand groups allows us to suggest a biocidal activity of the organotin component on the primary tumor node cells.
- Добавил в систему: Шпаковский Дмитрий Борисович
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