|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
An RNA virus-encoded zinc-finger protein acts as a plant transcription factor and induces a regulator of cell size and proliferation in two tobacco speciesстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 октября 2013 г.
- Авторы: Lukhovitskaya NI, Solovieva AD, Boddeti SK, Thaduri S., Solovyev AG, Savenkov EI
- Журнал: Plant Cell
- Том: 25
- Номер: 3
- Год издания: 2013
- Издательство: American Society of Plant Biologists
- Местоположение издательства: United States
- Первая страница: 960
- Последняя страница: 973
- DOI: 10.1105/tpc.112.106476
- Аннотация: Plant viruses cause a variety of diseases in susceptible hosts. The disease symptoms often include leaf malformations and other developmental abnormalities, suggesting that viruses can affect plant development. However, little is known about the mechanisms underlying virus interference with plant morphogenesis. Here, we show that a C-4 type zinc-finger (ZF) protein, p12, encoded by a carlavirus (chrysanthemum virus B) can induce cell proliferation, which results in hyperplasia and severe leaf malformation. We demonstrate that the p12 protein activates expression of a regulator of cell size and proliferation, designated upp-L (upregulated by p12), which encodes a transcription factor of the basic/helix-loop-helix family sufficient to cause hyperplasia. The induction of upp-L requires translocation of the p12 protein into the nucleus and ZF-dependent specific interaction with the conserved regulatory region in the upp-L promoter. Our results establish the role of the p12 protein in modulation of host cell morphogenesis. It is likely that other members of the conserved C-4 type ZF family of viral proteins instigate reprogramming of plant development by mimicking eukaryotic transcriptional activators.
- Добавил в систему: Соловьев Андрей Геннадьевич