Cationic Surfactants as Disinfectants against SARS-CoV-2

Karamov, E.V.; Larichev, V.F.; Kornilaeva, G.V.; Fedyakina, I.T.; Turgiev, A.S.; Shibaev, A.V.; Molchanov, V.S.; Philippova, O.E.; Khokhlov, A.R.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 13 июля 2022 г.

Авторы: Karamov Eduard V., Larichev Viktor F., Kornilaeva Galina V., Fedyakina Irina T., Turgiev Ali S., Shibaev Andrey V., Molchanov Vyacheslav S., Philippova Olga E., Khokhlov Alexei R.
Журнал: International Journal of Molecular Sciences
Том: 23
Номер: 12
Год издания: 2022
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Номер статьи: 6645
DOI: 10.3390/ijms23126645
Аннотация: The virucidal activity of a series of cationic surfactants differing in the length and number of hydrophobic tails (at the same hydrophilic head) and the structure of the hydrophilic head (at the same length of the hydrophobic n-alkyl tail) was compared. It was shown that an increase in the length and number of hydrophobic tails, as well as the presence of a benzene ring in the surfactant molecule, enhance the virucidal activity of the surfactant against SARS-CoV-2. This may be due to the more pronounced ability of such surfactants to penetrate and destroy the phospholipid membrane of the virus. Among the cationic surfactants studied, didodecyldimethylammonium bromide was shown to be the most efficient as a disinfectant, its 50% effective concentration (EC50) being equal to 0.016 mM. Two surfactants (didodecyldimethylammonium bromide and benzalkonium chloride) can deactivate SARS-CoV-2 in as little as 5 s.
Добавил в систему: Филиппова Ольга Евгеньевна

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Cationic Surfactants as Disinfectants against SARS-CoV-2статья

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