|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
Inhibition of histone deacetylases in the chick brain modulates expression of c-Fos and ZENK transcription factors and facilitates establishment of long-term memoryстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 9 марта 2017 г.
- Авторы: Toropova K.A., Anokhin K.V., Tiunova A.A.
- Журнал: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova
- Том: 64
- Номер: 5
- Год издания: 2014
- Издательство: Izdatel'stva Nauka
- Местоположение издательства: Russian Federation
- Первая страница: 551
- Последняя страница: 561
- DOI: 10.7868/S0044467714050116
- Аннотация: The aim of the work was to examine the role of histone acetylation in memory consolidation in newborn chicks. Wfe studied the effects of histone deacetylase inhibitor trichostatin A (TSA) on a “weak” memory for passive avoidance and on expression of two transcription factors c-Fos and ZENK known to play a role in neuronal plasticity in the chick brain. Intraventricular administration of trichostatin A prior to training produced a dose-dependent enhancement of memory when tested 24 hours after the training. It also increased neuronal expression of c-Fos and ZENK proteins: the density of ZENK immunopositive cells increased in the hippocampus and intermediate medial mesopallium and the density of c-Fos immunopositive cells increased in intermediate arcopallium and dorsocaudal nidopallium. Weak passive avoidance training did not produce further enhancement of c-Fos and ZENK expression in any of these brain areas. These data demonstrate possibility of facilitating long-term memory in day-old chicks by a histone deacetylases inhibitor, thus supporting the hypothesis on the role of histone acetylation in long-term memory formation. They also suggest that these effects might be mediated through modulation of transcriptional response in brain areas involved in consolidation of this form of memory. В© 2014, Maik Nauka-Interperiodica Publishing. All rights reserved.
- Добавил в систему: Торопова Ксения Александровна