Von Willebrand factor and ADAMTS-13 are associated with the severity of COVID-19 disease

Dolgushina, N.; Gorodnova, E.; Beznoshenco, O.; Romanov, A.; Menzhinskaya, I.; Krechetova, L.; Sukhikh, G.

Авторы: Dolgushina Nataliya, Gorodnova Elena, Beznoshenco Olga, Romanov Andrey, Menzhinskaya Irina, Krechetova Lyubov, Sukhikh Gennady
Журнал: JOURNAL OF CLINICAL MEDICINE
Том: 11
Номер: 14
Год издания: 2022
Номер статьи: 4006
DOI: 10.3390/jcm11144006
Аннотация: Coagulopathy in COVID-19 patients is presumably based on systemic hypercoagulation with the inflammatory response. As a result of endothelial dysfunction, tissue factor and von Willebrand factor (vWF) are released into the blood stream, which leads to prothrombinase activation. The vWF/ADAMTS-13 ratio can be used for monitoring the severity of the disease. This observational prospective study included 141 patients with COVID-19. In patients with mild COVID-19 (group 1), the assessment was performed on the 3rd–7th day of illness (point 1) and 14–28 days after recovery (point 2). In patients with moderate (groups 2) and severe (group 3) COVID-19, the assessment was performed during hospitalization (point 1) and after 14 days (point 2). The vWF:RCo/ADAMTS-13:activity (point 1), vWF/ADAMTS-13 (point 2) and vWF:RCo/ADAMTS-13:activity (point 2) ratios were significantly higher in patients with moderate and severe COVID-19. Moreover, in these patients, both ratios increased after recovery (point 2), which is a negative prognostic factor of thrombotic complications. Thus, COVID-19 is characterized by a decrease in the concentration and activity of ADAMTS-13 metalloproteinase, especially in patients with the severe form of COVID-19. A decrease in ADAMTS-13 activity results in an increase in vWF concentration and activity so the ratio of vWF to ADAMTS-13 changes significantly. View Full-TextKeywords: COVID-19; von Willebrand factor; ADAMTS-13; hypercoagulation; thrombosis
Добавил в систему: Романов Андрей Юрьевич

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Von Willebrand factor and ADAMTS-13 are associated with the severity of COVID-19 diseaseстатья

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