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Stem cell therapy for vocal fold regeneration after scarring: a review of experimental approachesстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Svistushkin Mikhail V., Kotova Svetlana, Shpichka Anastasia, Starostina Svetlana, Shekhter Anatoliy, Bikmulina Polina, Nikiforova Anna, Zolotova Anna, Royuk Valery, Kochetkov P.A., Timashev Serge, Fomin Victor, Vosough Massoud, Svistushkin Valery, Timashev Peter
- Журнал: Stem cell research & therapy
- Том: 13
- Номер: 1
- Год издания: 2022
- Издательство: BioMed Central
- Местоположение издательства: London
- DOI: 10.1186/s13287-022-02853-9
- Аннотация: This review aims at becoming a guide which will help to plan the experimental design and to choose adequate methods to assess the outcomes when testing cell-based products in the treatment of the damaged vocal folds. The requirements to preclinical trials of cell-based products remain rather hazy and dictated by the country regulations. Most parameters like the way the cells are administered, selection of the cell source, selection of a carrier, and design of in vivo studies are decided upon by each research team and may differ essentially between studies. The review covers the methodological aspects of preclinical studies such as experimental models, characterization of cell products, assessment of the study outcome using molecular, morphological and immunohistochemical analyses, as well as measuring the tissue physical properties. The unified recommendations to perform preclinical trials could significantly facilitate the translation of cell-based products into the clinical practice.
- Добавил в систему: Тимашев Петр Сергеевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | s13287-022-02853-9.pdf | 1,5 МБ | 3 августа 2022 [TPS_SU] |