Effects of Nitric Oxide on Protein-Lipid Interactions in the Membranes of the Myelinated Nerve Fiberстатья
Информация о цитировании статьи получена из
Web of Science
Статья опубликована в журнале из перечня ВАК
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 29 мая 2015 г.
Аннотация:We investigated the influence of nitric oxide (NO) on the myelinated nerve fiber and the impact of modification of SH-groups of axon and myelin membrane proteins on the amplitude and propagation velocity of action potential (AP), amount of the membrane-bound calcium (Ca(mb)(2+)), viscosity of the axon membrane, and saturation factor of phospholipid fatty acids (Sf) of myelin. We established that the decrease in the number of extracellular SH-groups in membrane proteins induced by p-chloromercuribenzoate (pCMB, 10(-4) M), led to a decrease in the AP amplitude and a reversible desorption of Ca(mb)(2+) but did not affect the axolemma viscosity and Sf. Nitric oxide (NO) caused a decrease in the AP amplitude and propagation velocity, an increase in the axolemma viscosity and a decrease in Sf of myelin; it also induced a reversible desorption of Ca(mb)(2+) . Pretreatment of the nerve fiber with pCMB weakened the NO-induced desorption of Ca(mb)(2+) Pretreatment of the nerve fiber with K(+)-channel net blocker tetraethylammonium (10(-2) M) completely abolished the NO-induced change in the amount of Ca(mb)(2+) . We suppose that NO-mediated changes in axolemma viscosity, Sf of myelin and desorption of Ca(mb)(2+) affect protein-lipid interactions in axolemma and myelin, which in their turn influence the propagation of AP.