Complexation of pH-Responsive Liposomal Nanocontainers with Polyanions for Manipulation with Release Properties and Adhesion to the Cell Surfacesстатья
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Аннотация:The impact of polyanions – sodium polystyrene sulfonate and sodiumpolyacrylate – on the rate of decapsulation of liposomal pH-sensitivenanocontainers is investigated. The release properties are studied by meansof laser microelectrophoresis and conductometery. Incorporation of capable tochange its conformation after protonationtrans-4,5-didodecyloxycarbonyl-2-morpholinocyclohexanol in electroneutralliposomes results in formation of pH-sensitive nanocontainers (fliposomes)that release payload in slight acidic media. Pairing of this fliposomes withpolyanions results in increase of rate of release of encapsulated water-solublecompounds. Strong polyacid is found to induce release even at neutral pH. Bymeans of fluorescence microscopy it is found that bare fliposomes beingadsorbed on model cell membranes in acidic media while modified withpolyanions nanocontainers provided release in intercellular environment.
