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COMPARATIVE STUDIES OF THE GENOTOXIC ACTIVITY OF A NEW PALLADIUM (II) ACIDOCOMPLEX AND CISPLATIN IN HUMAN BLOOD LYMPHOCYTES IN VITROстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 22 июля 2017 г.
- Авторы: Grekhova A.K., Gorbacheva L.B., Ivanova N.A., Efimenko I.A., Osipov A.N.
- Журнал: Biochemistry, Supplemental Series B
- Том: 7
- Номер: 3
- Год издания: 2013
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 226
- Последняя страница: 230
- DOI: 10.1134/S1990750813030050
- Аннотация: Comparative studies on the genotoxic activity of cisplatin and morfozol, the first representative of a new class of cation-anion complexes of palladium [AH]2[PdCl4] (where A—methylmorpholine), have been performed using human lymphocytes in vitro. The results of the DNA-DNA cross-linking activity investigations showed that both compounds studied exhibited biphasic dose-effect relationship: a linear decrease of the DNA percent in the comet tail and a plateau region. However, in the plateau region, morfozol caused a 6-fold reduction of the DNA percent in the comet tail while cisplatin caused a 2-fold decrease only. Morfozol, like cisplatin, inducing DNA-protein cross-linking and generating reactive oxygen species, was more effective than cisplatin.
- Добавил в систему: Осипов Андреян Николаевич