|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
A pentapeptide analogue of somatostatin as a vector for targeted delivery of radionuclides: А new pathway for the synthesis of a conjugateстатья
- Авторы: Khachatryan D.S., Osipov V.N., Retivov V.M., Kolotaev A.V.
- Журнал: Current Topics in Peptide and Protein Research
- Том: 22
- Год издания: 2021
- Издательство: Research Trends
- Местоположение издательства: India
- Первая страница: 145
- Последняя страница: 156
- Аннотация: Currently targeted therapy is one of the major methods of medical treatment for cancer. The creation of new radiopharmaceuticals to treat and diagnose neuroendocrine tumors expressing somatostatin receptors is a topical task that is needed to increase their selectiveness and to overcome tumor resistance that occurs. The search for new vectors and more efficient conjugates is required for this goal. A new method of conjugate synthesis based on pentapeptides (somatostatin analogs) containing the aryl-substituted thiazolidinecarboxylic acids was developed. The most optimal ethylenediamine is proposed as a linker, binding the vector with the chelator.
- Добавил в систему: Осипов Василий Николаевич