Conjugates of Desmycosin with Fragments of Antimicrobial Peptide Oncocin: Synthesis, Antibacterial Activity, Interaction with Ribosome

Khairullina, Z.Z.; Makarov, G.I.; Tereshchenkov, A.G.; Buev, V.S.; Lukianov, D.A.; Polshakov, V.I.; Tashlitsky, V.N.; Osterman, I.A.; Sumbatyan, N.V.

Авторы: Khairullina Zimfira Z., Makarov Gennady I., Tereshchenkov Andrey G., Buev Vitaly S., Lukianov Dmitrii A., Polshakov Vladimir I., Tashlitsky Vadim N., Osterman Ilya A., Sumbatyan Natalia V.
Журнал: Biochemistry (Moscow)
Том: 87
Номер: 9
Год издания: 2022
Издательство: Pleiades Publishing, Ltd
Местоположение издательства: Road Town, United Kingdom
Первая страница: 871
Последняя страница: 889
Оригинальные версии: Конъюгаты десмикозина с фрагментами антимикробного пептида онкоцина: синтез, антибактериальная активность, взаимодействие с рибосомой
DOI: 10.1134/s0006297922090024
Аннотация: Design and synthesis of conjugates consisting of the macrolide antibiotic desmycosin and fragments of the antibacterial peptide oncocin were performed in attempt to develop new antimicrobial compounds. New compounds were shown to bind to the E. coli 70S ribosomes, to inhibit bacterial protein synthesis in vitro, as well as to suppress bacterial growth. The conjugates of N-terminal hexa- and tripeptide fragments of oncocin and 3,2′,4′′-triacetyldesmycosin were found to be active against some strains of macrolide-resistant bacteria. By simulating molecular dynamics of the complexes of these compounds with the wild-type bacterial ribosomes and with ribosomes, containing A2059G 23S RNA mutation, the specific structural features of their interactions were revealed.
Добавил в систему: Макаров Геннадий Иванович

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Conjugates of Desmycosin with Fragments of Antimicrobial Peptide Oncocin: Synthesis, Antibacterial Activity, Interaction with Ribosomeстатья Исследовательская статья

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