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Identification of proteins specifically interacting with YB-1 mRNA 3' UTR and the effect of hnRNP Q on YB-1 mRNA translationстатья
- Авторы: Lyabin D.N., Nigmatullina L.F., Doronin A.N., Eliseeva I.A., Ovchinnikov L.P.
- Журнал: Biochemistry (Moscow)
- Том: 78
- Номер: 13
- Год издания: 2013
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 651
- Последняя страница: 659
- DOI: 10.1134/S0006297913060102
- Аннотация: In this study, proteins specifically interacting with the 3' untranslated region (UTR) of mRNA of the multifunctional Y-box-binding protein 1 (YB-1) were identified. One of these, hnRNP Q, was shown to specifically interact with the regulatory element (RE) in YB-1 mRNA 3' UTR and to inhibit translation of this mRNA. Its binding to the RE was accompanied by displacement from this element of the poly(A)-binding protein (PABP), a positive regulator of YB-1 mRNA translation, and by enhanced binding of the negative YB-1 mRNA translation regulator - YB-1 itself.
- Добавил в систему: Лябин Дмитрий Николаевич