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Synthesis of the first conjugates of 5-ethynyl-2′-deoxyuridine with closo-dodecaborate and cobalt-bis-dicarbollide boron clusters” Tetrahedronстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 марта 2017 г.
- Авторы: Semioshkin A., Ilinova A., Lobanova I., Bregadze V., Paradowska E., Studzińska M., Jabłońska A., Lesnikowski Z.J.
- Журнал: Tetrahedron
- Том: 69
- Год издания: 2013
- Издательство: Pergamon Press Ltd.
- Местоположение издательства: United Kingdom
- Первая страница: 8034
- Последняя страница: 8041
- DOI: 10.1016/j.tet.2013.06.100
- Аннотация: A new 2'-deoxyuridine modification, 3',5'-bis-(dimethyl-t-butylsilyl)-5-(3-(2-(dimethylamino)ethoxy)-3-methylbutyn-1-yl)-2'-deoxyuridine was effectively synthesized in four easy steps. Its reactivity towards a range of cyclic oxonium adducts of closo-dodecaborate and cobalt-bis-dicarbollide boron clusters was studied. The cleavage reactions of cluster oxonium rings by the N,N-dimethylamino group of the modified nucleoside led to 5-ethynyl-2'-deoxyuridine conjugates with [B12H12]2- and [Co(C2B9H11)2]-, respectively. Cytotoxicity of these new conjugates in several cell lines was examined. Closo-dodecaborate conjugates showed low cytotoxicity in all examined cell lines, an advantageous and preferred property for potential boron delivering drugs for the boron neutron capture therapy (BNCT) of tumors.
- Добавил в систему: Семиошкин Андрей Анатольевич