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The Role of Cyclomodulins and Some Microbial Metabolites in Bacterial Microecology and Macroorganism Carcinogenesisстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Markelova N.N., Semenova E.F., Sineva O.N., Sadykova V.S.
- Журнал: International Journal of Molecular Sciences
- Том: 23
- Год издания: 2022
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Номер статьи: 11706
- Аннотация: A number of bacteria that colonize the human body produce toxins and effectors that causechanges in the eukaryotic cell cycle—cyclomodulins and low-molecular-weight compounds suchas butyrate, lactic acid, and secondary bile acids. Cyclomodulins and metabolites are necessary forbacteria as adaptation factors—which are influenced by direct selection—to the ecological nichesof the host. In the process of establishing two-way communication with the macroorganism, thesecompounds cause limited damage to the host, despite their ability to disrupt key processes in eukaryotic cells, which can lead to pathological changes. Possible negative consequences of cyclomodulinand metabolite actions include their potential role in carcinogenesis, in particular, with the abilityto cause DNA damage, increase genome instability, and interfere with cancer-associated regulatorypathways. In this review, we aim to examine cyclomodulins and bacterial metabolites as importantfactors in bacterial survival and interaction with the host organism to show their heterogeneous effecton oncogenesis depending on the surrounding microenvironment, pathological conditions, and hostgenetic background.
- Добавил в систему: Садыкова Вера Сергеевна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | ijms-23-11706.pdf | 1,1 МБ | 3 октября 2022 [sadykovavs] |