Mitochondria-targeted antioxidants as a prospective therapeutic strategy for multiple sclerosis

Fetisova, E.; Chernyak, B.; Korshunova, G.; Muntyan, M.; Skulachev, V.

Авторы: Fetisova Elena, Chernyak Boris, Korshunova Galina, Muntyan Maria, Skulachev Vladimir
Журнал: Current Medicinal Chemistry
Том: 24
Номер: 19
Год издания: 2017
Издательство: Bentham Science Publishers
Местоположение издательства: Netherlands
Первая страница: 2086
Последняя страница: 2114
DOI: 10.2174/0929867324666170316114452
Аннотация: Background: Multiple sclerosis (MS) is one of the most widespread chronic neurological diseases that manifests itself by progressive demyelination in the central nervous system. The study of MS pathogenesis begins with the onset of the relapsing–remitting phase of the disease, which becomes apparent due to microglia activation, neuroinflammation and demyelination/remyelination in the white matter. The following progressive phase is accompanied by severe neurological symptoms when demyelination and neurodegeneration are spread to both gray and white matter. In this review, we discuss a possible role of mitochondrial reactive oxygen species (mtROS) in MS pathogenesis, mechanisms of mtROS generation and effects of some mitochondria-targeted antioxidants as potential components of MS therapy. Results: In the early phase of MS, mtROS stimulate NLRP3 inflammasomes, which is critical for the formation of local inflammatory lesions. Later, mtROS contribute to blood-brain barrier disruption induced by mediators of inflammation, followed by infiltration of leukocytes. ROS generated by leukocytes and activated microglia promote mitochondrial dysfunction and oligodendrocyte cell death. In the progressive phase, neurodegeneration also depends on excessive mtROS generation. Currently, only a few immunomodulatory drugs are approved for treatment of MS. These drugs mainly reduce the number of relapses but do not stop MS progression. Certain dietary and synthetic antioxidants have demonstrated encouraging results in animal models of MS but were ineffective in the completed clinical trials. Conclusion: Novel mitochondria-targeted antioxidants could be promising components of combined programs for MS therapy considering that they can be applied at extremely low doses and concurrently demonstrate anti-inflammatory and neuroprotective activities.
Добавил в систему: Мунтян Мария Сергеевна

	ИСТИНА	Войти в систему Регистрация
	ИПМех РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

ИПМех РАН

Mitochondria-targeted antioxidants as a prospective therapeutic strategy for multiple sclerosisстатья Исследовательская статья

Прикрепленные файлы