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Lighting up Nobel Prize-winning studies with protein intrinsic disorderстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Piersimoni L., Abd El Malek M., Bhatia T., Bender J., Brankatschk C., Calvo Sánchez J., Dayhoff G.W., Di Ianni A., Figueroa Parra J.O., Garcia-Martinez D., Hesselbarth J., Köppen J., Lauth L.M., Lippik L., Machner L., Sachan S., Schmidt L., Selle R., Skalidis I., Sorokin O., Ubbiali D., Voigt B., Wedler A., Wei A.A.J, Zorn P., Dunker A.K., Köhn M., Sinz A., Uversky V.N.
- Журнал: Cellular and Molecular Life Sciences
- Том: 79
- Номер: 8
- Год издания: 2022
- Издательство: Birkhauser Verlag
- Местоположение издательства: Switzerland
- Первая страница: 449
- Аннотация: Intrinsically disordered proteins and regions (IDPs and IDRs) and their importance in biology are becoming increasingly recognized in biology, biochemistry, molecular biology and chemistry textbooks, as well as in current protein science and structural biology curricula. We argue that the sequence → dynamic conformational ensemble → function principle is of equal importance as the classical sequence → structure → function paradigm. To highlight this point, we describe the IDPs and/or IDRs behind the discoveries associated with 17 Nobel Prizes, 11 in Physiology or Medicine and 6 in Chemistry. The Nobel Laureates themselves did not always mention that the proteins underlying the phenomena investigated in their award-winning studies are in fact IDPs or contain IDRs. In several cases, IDP- or IDR-based molecular functions have been elucidated, while in other instances, it is recognized that the respective protein(s) contain IDRs, but the specific IDR-based molecular functions have yet to be determined. To highlight the importance of IDPs and IDRs as general principle in biology, we present here illustrative examples of IDPs/IDRs in Nobel Prize-winning mechanisms and processes.
- Добавил в систему: Уверский Владимир Николаевич