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An issue of concern: unique truncated ORF8 protein variants of SARS-CoV-2статья
- Авторы: Hassan S.S., Kodakandla V., Redwan E.M., Lundstrom K., Pal Choudhury P., Abd El-Aziz T.M., Takayama K., Kandimalla R., Lal A., Serrano-Aroca Á., Azad G.K., Aljabali A.A.A, Palù G., Chauhan G., Adadi P., Tambuwala M., Brufsky A.M., Baetas-da-Cruz W., Barh D., Azevedo V., Bazan N.G., Andrade B.S., Santana Silva R.J., Uversky V.N.
- Журнал: PeerJ
- Том: 10
- Год издания: 2022
- Издательство: PeerJ
- Местоположение издательства: San Francisco
- Первая страница: e13136
- Аннотация: Open reading frame 8 (ORF8) shows one of the highest levels of variability among accessory proteins in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Disease 2019 (COVID-19). It was previously reported that the ORF8 protein inhibits the presentation of viral antigens by the major histocompatibility complex class I (MHC-I), which interacts with host factors involved in pulmonary inflammation. The ORF8 protein assists SARS-CoV-2 in evading immunity and plays a role in SARS-CoV-2 replication. Among many contributing mutations, Q27STOP, a mutation in the ORF8 protein, defines the B.1.1.7 lineage of SARS-CoV-2, engendering the second wave of COVID-19. In the present study, 47 unique truncated ORF8 proteins (T-ORF8) with the Q27STOP mutations were identified among 49,055 available B.1.1.7 SARS-CoV-2 sequences. The results show that only one of the 47 T-ORF8 variants spread to over 57 geo-locations in North America, and other continents, which include Africa, Asia, Europe and South America. Based on various quantitative features, such as amino acid homology, polar/non-polar sequence homology, Shannon entropy conservation, and other physicochemical properties of all specific 47 T-ORF8 protein variants, nine possible T-ORF8 unique variants were defined. The question as to whether T-ORF8 variants function similarly to the wild type ORF8 is yet to be investigated. A positive response to the question could exacerbate future COVID-19 waves, necessitating severe containment measures.
- Добавил в систему: Уверский Владимир Николаевич