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Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and functionстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Hassan S.S., Lundstrom K., Serrano-Aroca Á., Adadi P., Aljabali A.A.A, Redwan E.M., Lal A., Kandimalla R., El-Aziz T.M.A, Pal Choudhury P., Azad G.K., Sherchan S.P., Chauhan G., Tambuwala M., Takayama K., Barh D., Palu G., Basu P., Uversky V.N.
- Журнал: International Journal of Biological Macromolecules
- Том: 194
- Год издания: 2022
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 128
- Последняя страница: 143
- Аннотация: The devastating impact of the ongoing coronavirus disease 2019 (COVID-19) on public health, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has made targeting the COVID-19 pandemic a top priority in medical research and pharmaceutical development. Surveillance of SARS-CoV-2 mutations is essential for the comprehension of SARS-CoV-2 variant diversity and their impact on virulence and pathogenicity. The SARS-CoV-2 open reading frame 10 (ORF10) protein interacts with multiple human proteins CUL2, ELOB, ELOC, MAP7D1, PPT1, RBX1, THTPA, TIMM8B, and ZYG11B expressed in lung tissue. Mutations and co-occurring mutations in the emerging SARS-CoV-2 ORF10 variants are expected to impact the severity of the virus and its associated consequences. In this article, we highlight 128 single mutations and 35 co-occurring mutations in the unique SARS-CoV-2 ORF10 variants. The possible predicted effects of these mutations and co-occurring mutations on the secondary structure of ORF10 variants and host protein interactomes are presented. The findings highlight the possible effects of mutations and co-occurring mutations on the emerging 140 ORF10 unique variants from secondary structure and intrinsic protein disorder perspectives.
- Добавил в систему: Уверский Владимир Николаевич